Entrepreneurship in Biotechnology

1 Independent Biopharmaceutical Companies and Their Specialization in Drug Discovery Technologies. - 1. 1 Drug Discovery in Research and Development Pipelines. - 1. 2 Growth Problems Generated by R&D Duration. - 1. 3 Consequences of Human Genetic Research on Drug Discovery. - 2 Model Structure for High-Technology Firms and Its Dynamic Behavior in Start-Up Phases. - 2. 1 Macro Structure for Entrepreneurial Management of Start-Ups. - 2. 2 Micro Structure that Determines High-Technology Performance. - 2. 3 Dynamic Behavior from Start-Up Model Experiments. - 3 Model Structure and Dynamic Behavior for High-Technology Firms in Transition to Growth Phases. - 3. 1 Macro Structure for Contract Research. - 3. 2 Micro Structure for Contract Research on Novel Disease Targets. - 3. 3 Dynamic Behavior from Transition Model Experiments. - 4 Economic Value Creation in Transition Phases: Access to Equity Capital. - 4. 1 Value Creation from Drug Candidates in Collaborative R&D Pipelines. - 4. 2 Simulation of Value Creation. -4. 3 Equity Financing for Growth Phases. - 5 Strategies for Growth Phases to Sustain Independence. - Appendix 1: Parameter List for Start-Up Model. - Appendix 2: List of Equations for Start-Up Model. - Appendix 3: Parameter List for Transition Model. - Appendix 4: A Dynamic Theory on Cost of Capital for Biotechnology Firms.