Chemical Mixtures and Combined Chemical and Nonchemical Stressors

Exposure to multiple chemical and nonchemical stressors is the rule, not the exception. Nevertheless, it continues to be a significant challenge in toxicology and risk assessment to thoroughly take mixtures into account. In this book, both basic and advanced concepts for considering mixtures are discussed, from initial-exposure characterization through the evaluation of risk associated with combined exposures. Several chapters also examine the adoption of promising tools from other disciplines. Looking beyond chemical mixtures, the discussion also addresses incorporating nonchemical stressors into toxicity studies and cumulative-risk assessments.

This "excellent" volume-as described by Linda S. Birnbaum, Director of the National Institute of Environmental Health Sciences and the National Toxicology Program, in her foreword to the book-forms "a comprehensive picture of the current state of mixtures science." With contributions from a host of established experts, Chemical Mixtures and Combined Chemical and Nonchemical Stressors: Exposure, Toxicity, Analysis, and Risk is an essential text for mixtures researchers in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics. Both seasoned mixtures researchers and those new to the field will appreciate the clear explanations of mixtures concepts as well as the comprehensive presentation of available tools for predicting mixture effects and estimating risk from combined exposures. This volume also serves as a useful reference book for students.

Introduction.- Combined exposures.-Measuring combined exposures.- Modeling complex exposures.-Prioritizing mixtures for study.- Environment-Wide Association Studies.- Biogeographical analysis of chemical co-occurrence.- Combining exposure and toxicity information to develop logical groupings for assessment.- Maximum Cumulative Ratio for deciding when to assess mixtures .- Establishing the no interaction baseline.- Dose addition models .- Response addition.- Integrated addition.- Mixture statistics comparing predicted to observed.- Cumulative Risk Assessment.- Deciding which approach to use.- Component-based approaches.- Sufficient similarity of whole mixtures.- Other whole mixtures approaches .- Assessing interactions.- Likelihood and examples of chemical interactions.- PBPK modeling of chemical interactions.- Adding interactions to cumulative risk assessment.- Consideration of nonchemical stressors.- Toxicity and interactions of physical and chemical stressors.- Psychosocial and chemical stressors.- Adding nonchemical stressors to cumulative risk assessments.- Disease-based risk assessment.- Community-based risk assessment.