Leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to the prevention, diagnosis, and treatment. The authors' cross-disciplinary approach, with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa, reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA micoarrays and the impact of genome sequencing comparisons on the discovery and choices of novel drug targets. The result is a better understanding how genomic information can reveal the fundamentals of microbial pathogenesis and how organisms interact with their host environment.
Inhaltsverzeichnis
I Viruses.- 1 Antiviral Drug Target Discovery with DNA Microarrays.- 2 Chipping Away at HIV Pathogenesis.- 3 Microarray Analysis of Human Papillomavirus Pathogenesis.- 4 Ribozymes as Gene Therapeutic Agents for HIV/AIDS: A Potential Paradigm Shift.- II Bacteria.- 5 Genomics and New Technologies Applied to Antibacterial Drug Discovery.- 6 Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines.- 7 Bacterial Genes-to-Screens in the Post-Genomic Era.- 8 DNA Microarray Expression Analysis in Antibacterial Drug Discovery.- 9 The Influence of Genomics on the Molecular Epidemiology of Nosocomial Pathogens.- 10 Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development.- III Fungi.- 11 Antifungal Target Discovery and Evaluation: Lessons from Saccharomyces cerevisiae.- 12 Antifungal Drug Discovery: Old Drugs, New Tools.- 13 Cryptococcus neoformans: A Molecular Model for the Study of Fungal Pathogenesis and Drug Discovery in the Genomic Era.- 14 Antifungal Target Selection in Aspergillus nidulans: Using Bioinformatics to Make the Difference.- 15 Functional Genomics of Histoplasma capsulatum: Dimorphism and Virulence.- 16 Gene Finding in Coccidioides immitis: Searching for Immunogenic Proteins.- IV Protozoa.- 17 Toxoplasma gondii: A Model for Evolutionary Genomics and Chemotherapy.- 18 The Molecular Biology and Pathogenicity of Entamoeba histolytica.
