Genome sequencing and analysis have yielded a rich harvest of fundamental information about pathogenesis and have raised significant new possibilities for effective therapeutic intervention. In Pathogen Genomics: Impact on Human Health, a panel of leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to infectious disease prevention, diagnosis, and treatment. The authors' cross-disciplinary approach-with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa-reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA microarrays and the impact of genome sequencing comparisons to the discovery and choices of novel drug targets. The result is a better understanding of how these tools can be used to explore the fundamentals of microbial pathogenesis, as well as how pathogens interact with each other and with their host environments.
Broad-ranging and illuminating, Pathogen Genomics: Impact on Human Health offers today's infectious disease specialists an authoritative analysis of the new genomic technologies and their productive application to drug discovery, vaccine development, and diagnostics.
Inhaltsverzeichnis
I Viruses.- 1 Antiviral Drug Target Discovery with DNA Microarrays.- 2 Chipping Away at HIV Pathogenesis.- 3 Microarray Analysis of Human Papillomavirus Pathogenesis.- 4 Ribozymes as Gene Therapeutic Agents for HIV/AIDS: A Potential Paradigm Shift.- II Bacteria.- 5 Genomics and New Technologies Applied to Antibacterial Drug Discovery.- 6 Genomics of the Mycobacterium tuberculosis Complex and BCG Vaccines.- 7 Bacterial Genes-to-Screens in the Post-Genomic Era.- 8 DNA Microarray Expression Analysis in Antibacterial Drug Discovery.- 9 The Influence of Genomics on the Molecular Epidemiology of Nosocomial Pathogens.- 10 Borrelia Genomics as a Tool for Studying Pathogenesis and Vaccine Development.- III Fungi.- 11 Antifungal Target Discovery and Evaluation: Lessons from Saccharomyces cerevisiae.- 12 Antifungal Drug Discovery: Old Drugs, New Tools.- 13 Cryptococcus neoformans: A Molecular Model for the Study of Fungal Pathogenesis and Drug Discovery in the Genomic Era.- 14 Antifungal Target Selection in Aspergillus nidulans: Using Bioinformatics to Make the Difference.- 15 Functional Genomics of Histoplasma capsulatum: Dimorphism and Virulence.- 16 Gene Finding in Coccidioides immitis: Searching for Immunogenic Proteins.- IV Protozoa.- 17 Toxoplasma gondii: A Model for Evolutionary Genomics and Chemotherapy.- 18 The Molecular Biology and Pathogenicity of Entamoeba histolytica.
