Although there have been many books on HIV and AIDS, surprisingly little has been published that focuses on the immunology of retroviral infections in general, and HIV in particular. Retroviral Immunology: Immune Response and Restoration is the first book of its kind to address the most important aspects of the immunology of retroviruses, including not only the virus-specific immune responses, but also genetic and virologic factors modulating these responses. The book also deals directly with the emerging concept of immune restora tion in retroviral infections, a particularly important subject to the thousands of clinicians who deal with this problem on a daily basis. With the advent of highly effective antiviral drug regimens to slow down the replication of HIV and the progression of AIDS, new challenges and opportunities are arising. Restoration of general immune function has brought with it not only complica tions of immune restoration-mediated disease, but also the realistic hope for meaningful restoration of the ability to control HIV replication with the immune system. Leading scientists in the field have summarized the most current informa tion regarding experimental and clinical aspects of retroviral infections. Retroviral Immunology: Immune Response and Restoration should prove an impor tant point of reference for basic scientists and clinicians in this area of research. We are indebted to all of our authors for their excellent contributions.
Inhaltsverzeichnis
1 Epidemiological and Immunological Implications of the Global Variability of HIV-1.- 2 Role of Chemokines and Their Receptors in the Pathogenesis of HIV Infection.- 3 Cytokines and Chemokines in HIV Infection.- 4 Development and Reconstitution of T-Lymphoid Immunity.- 5 HIV Gene Products as Manipulators of the Immune System.- 6 Immune Response to Murine and Feline Retroviruses.- 7 Immune Response to HTLV-I and HTLV-II.- 8 HIV-Specific Neutralizing Antibodies.- 9 Cytotoxic T-Cell Responses in Acute and Chronic HIV-1 Infection.- 10 Characterization of the HIV-1 Specific T-Helper Cell Response.- 11 Immune Responses to Nonhuman Primate Lentiviruses.- 12 Intrahost Selective Pressure and HIV-1 Heterogeneity During Progression to AIDS.- 13 Polymorphism in HLA and Other Elements of the Class I and II Response Pathways.- 14 Immunologic Approaches to the Therapy of Patients with HIV Infection.
