Over the last decade much has been written about HIV and AIDS, although there has been surprisingly very little written on the immunology of retroviral infections, in general, and on HIV in particular. In Retroviral Immunology: Immune Response and Restoration, world-renowned authorities address the most important aspects of the immunology of retroviruses, namely, immune response, genetic and virologic factors modulating the response, and the HIV-specific humoral and cell-mediated responses. In addition to the basic concepts of immune restoration, key topics covered include immune restoration after antiviral therapy-a highly important subject to the thousands of clinicians who deal with the problem on a daily basis-and vaccine-induced immune response.
Up-to-date and authoritative, Retroviral Immunology: Immune Response and Restoration provides a much-needed critical synthesis of both the experimental and clinical aspects of retroviral infections, and lays the groundwork for developing effective restoration strategies for the many immune-compromised HIV and AIDS patients who suffer fatal opportunistic infections.
Inhaltsverzeichnis
1 Epidemiological and Immunological Implications of the Global Variability of HIV-1.- 2 Role of Chemokines and Their Receptors in the Pathogenesis of HIV Infection.- 3 Cytokines and Chemokines in HIV Infection.- 4 Development and Reconstitution of T-Lymphoid Immunity.- 5 HIV Gene Products as Manipulators of the Immune System.- 6 Immune Response to Murine and Feline Retroviruses.- 7 Immune Response to HTLV-I and HTLV-II.- 8 HIV-Specific Neutralizing Antibodies.- 9 Cytotoxic T-Cell Responses in Acute and Chronic HIV-1 Infection.- 10 Characterization of the HIV-1 Specific T-Helper Cell Response.- 11 Immune Responses to Nonhuman Primate Lentiviruses.- 12 Intrahost Selective Pressure and HIV-1 Heterogeneity During Progression to AIDS.- 13 Polymorphism in HLA and Other Elements of the Class I and II Response Pathways.- 14 Immunologic Approaches to the Therapy of Patients with HIV Infection.
