This set reports the results of the 10th International Histocompatibility Workshop, in which 362 laboratories collaborated over a three year period in research projects on the classification of HLA genes and their products. Volume 1 describes the experimental design of the workshop studies and their results. Volume 2 is a collection of papers on the latest developments in the molecular biology of HLA systems. Immunobiology of HLA is a valuable reference for tissue typing laboratories, blood banks, and general research programs on HLA and related diseases because it identifies common sources of HLA genes and gene products to be used as reference reagents, and because it is the only complete compilation of the latest research and results in the field.
Inhaltsverzeichnis
of Volume I.- Overview.- Overview of Experimental Design for the Tenth International Histocompatibility Workshop.- Reference Panel of B-Lymphoblastoid Cell Lines for Factors of the HLA System.- Description of the Reference Panel of B-Lymphoblastoid Cell Lines for Factors of the HLA System: The B-Cell Line Panel Designed for the Tenth International Histocompatibility Workshop.- Serologic Characterization of the Reference Panel of B-Lymphoblastoid Cell Lines for Factors of the HLA System.- HLA-Dw and HLA-DP Typing of the Reference Panel of B-Lymphoblastoid Cell Lines.- Assignment of HLA-A and HLA-B Antigens for the Reference Panel of B-Lymphoblastoid Cell Lines Determined by One-Dimensional Isoelectric Focusing (1D-IEF) Gel Electrophoresis.- Assignment of HLA-Class II ? and ? Chain 2-D Gel Patterns for the Workshop Reference Panel of B-Lymphoblastoid Cell Lines.- Assignment of T-Cell-Defined (TCD) HLA Class II Specificities for the Reference Panel of B-Lymphoblastoid Cell Lines.- Nomenclature for Factors of the HLA System.- New HLA Specificities and Provisional HLA Determinants Defined by the Tenth International Histocompatibility Workshop.- New HLA Antigens Identified in the Serologic Studies of the Tenth International Histocompatibility Workshop, 1987.- Nomenclature for HLA-A and HLA-B Alleles Detected by One-Dimensional Isoelectric Focusing (1D-IEF) Gel Electrophoresis.- Nomenclature for Two-Dimensional (2-D) Gel Patterns of the HLA Class II ? and ? Chains Defined in the Tenth Workshop.- Nomenclature for T-Cell-Defined HLA Class II Determinants.- Nomenclature for HLA-RFLP.- Nomenclature for Factors of the HLA System, 1987.- Joint Reports: Data Collection and Central Analysis.- Tenth International Histocompatibility Workshop: Overview of Data Processing and Analysis.- Display of Correlation Structures.- Joint Reports: Serology.- Serologic Exercises of the Tenth Workshop.- Data Processing and Serum Analysis.- Pattern Analysis.- Cell Typing.- Antigen Society #1 Report (A1, Aw36, A3, A11, A9, A23, A24).- Antigen Society #2 Report (A25, A26, AW34, AW43, and AW66).- Antigen Society #3 Report (AW19 and A32/Aw74).- Antigen Society #4 Report (A2, AW68, AW69 and A28).- Antigen Society #5 Report (B5, B51, Bw52, B18, B35, Bw53).- Antigen Society #6 Report (B21, B49, Bw50, BN21, B12, B44, B45).- Antigen Society #7 Report (B8, w59, B14, w64, w65).- Antigen Society #8 Report (Bw70, Bw71, Bw72).- Antigen Society #9 Report (Bw46 and the Subgroups of B15).- Antigen Society #10 Report (Bw57 and Bw58).- Antigen Society #11 Report (B37, B38, B39, and Bw67).- Antigen Society #12 Report (Bw54, Bw55, Bw56 and Bw42).- Antigen Society #13 Report (B7, B27, Bw47, Bw73).- Antigen Society #13 Report (B7, B27, Bw47, Bw73): Public Determinants of the HLA-B7 CREG Defined by Antibodies and T-Cell Clones.- Antigen Society #13 Report (B7, B27, Bw47, Bw73): Six Subtypes of HLA-B7 Defined by Histotypes, Epitopes and 1D-IEF.- Antigen Society #14 Report (B40 CREG, BW60, BW61, BW41, BW48, B13).- Antigen Society #15 Report (Bw4 and Bw6).- Antigen Society #16 Report (Cw1, Cw3, Cw9, Cw10, Cw11).- Antigen Society #17 Report (Cw5 and Cw8).- Antigen Society #18 Report (Cw4 and Cw6).- Antigen Society #19 Report (Cw7).- Antigen Society #20 Report (Cw2).- Antigen Society #21 Report (DR1, DRw10).- Antigen Society #22 Report (DR2).- Antigen Society #23 Report (DR4, DR9): Part. 1: Analysis of Core and Antigen Society #23 Panel Data.- Antigen Society #23 Report (DR4, DR9): Part 2: Serologic Typing of B-Lymphoblastoid Cell Lines: DR 4 and DR9.- Antigen Society #24 Report (DRw11, DRw12, DRw8).- Antigen Society #25 Report (DRw6, DRw13, DRw14).- Antigen Society #26 Report (DR3, DR7, DQw2): Part 1.- Antigen Society #26 Report (DR3, DR7, DQw2): Part 2: HLA-DR3.- Antigen Society #26 Report (DR3, DR7, DQw2) Part 3: Serologic Definition of HLA-DR7.- Antigen Society #26 Report (DR3, DR7, DQw2): Part 4: HLA-DQw2.- Antigen Society #27 Report (DQw1).- Antigen Society #28 Report (DQw3).- Antigen Society #29 Report (DRw52).- Antigen Society #30 Report (DRw53).- Antigen Society #31 Report (Qa and TL-Like Antigens) Part 1: The Leiden Class IV or Class I-like Workshop.- Antigen Society #31 Report Part 2: Antigen Society #31 Report.- Antigen Society #31 Report Part 3: Leukemic Blasts Express New HLA Class I-Like Alloantigens.- Antigen Society #32 Report (DP).- Antigen Society #33 Report (Public Epitopes).- Antigen Society #35 Report (DQw4 [DQ WA ]).- Micro EIA and Monoclonal Antibodies.- Cytotoxic Monoclonal Antibodies.- Joint Reports: HLA Class I Polymorphism Detected by One-Dimensional Isoelectric Focusing.- Population Analysis of Class I HLA Antigens by One-Dimensional Isoelectric Focusing Gel Electrophoresis: Workshop Summary Report.- A Standardized Method for Detection of HLA-A and HLA-B Alleles by One-Dimensional Isoelectric Focusing (IEF) Gel Electrophoresis.- Detection of HLA-Cw3 Subtypes and a New HLA-C Antigen by One-Dimensional Isoelectric Focusing (1D-IEF).- Identification of HLA-C Locus Products by One-Dimensional Isoelectric Focusing (1D-IEF).- Serological Definition of HLA-A2 Variants.- Variants of HLA-Aw68 Recognized by Isoelectric Focusing.- Biochemical Variants of the Bw70 Antigen (Bw71, Bw72).- B SNA : HLA-B5 Split Associated with Bw6 Studied by Serology and 1D-IEF.- B40 CREG Variants Detected by Serology, IEF, and CTL.- Serology and IEF Analysis of New HLA-B Locus Gene Products B POT, B RI, B ST40, and B LEV .- HLA Class I Typing by Computer Analysis of 1D-IEF Data.- Segregation Analysis of HLA Class I Determinants by Biochemistry.- Charge Variants of HLA-A and B Gene Products.- Joint Reports: T-Cell Recognition of HLA Class I Molecules.- T-Cell Recognition of HLA Class I Molecules.- Joint Reports: Structural Polymorphism of the HLA Class II Alpha and Beta Chains.- Structural Polymorphism of the HLA Class II ? and ? Chains: Summary of the 10th Workshop 2-D Gel Analysis.- DR1: 2-D Gel Patterns.- DR2 (DRw15, 16): 2-D Gel Patterns.- DR3 (DRw17, DRw18) 2-D Gel Patterns.- DR4: 2-D Gel Patterns.- DR5 (DRw11, DRw12): 2-D Gel Patterns.- DRw6 (DRw13, DRw14): 2-D Gel Patterns.- DR7: 2-D Gel Patterns.- DRw8: 2-D Gel Patterns.- DR9: 2-D Gel Patterns.- DRw52: 2-D Gel Patterns.- DRw53: 2-D Gel Patterns.- DQw1 (DQw5, DQw6): 2-D Gel Patterns.- DQw2: 2-D Gel Patterns.- DQw3 (DQw7, DQw8, DQw9): 2-D Gel Patterns.- DQw4 (Wa): 2-D Gel Patterns.- DP? Chains: 2-D Gel Patterns.- Binding Patterns of the Monoclonal Antibodies in the 10th Workshop 2-D Gel Analysis of Class II Antigens.- Standardized Equipment, Reagents, and Techniques Developed for the 10th Workshop 2-D Gel Study of HLA Class II Antigens.- Computerized Analysis of 2-D Gel Patterns of the HLA Class II Antigens.- Joint Reports: T-Cell Recognition of HLA Class II Molecules.- Preface.- Background, Goals, and Experimental Design.- Collection and Processing of HLA Class II Cellular Data.- Statistical Analysis of HLA Class II Cellular Data.- Immunogenetic Analysis of HLA Class II Cellular Data.- DR1: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DR2: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DR3: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DR4 and DQw3: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DR5: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DRw6: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DR7, DQw2, and DRw53: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DRw8 and DQw4: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DRw52: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DQw1: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- DP: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- T-cell Clones Recognizing Shared or Cross-Reactive Epitopes: Antigen Report of the Cellular Studies of the Tenth International Histocompatibility Workshop.- Functional Polymorphisms of HLA Class II Gene Products Detected by T-Lymphocyte Clones: Summary of the Tenth International Histocompatibility Workshop Cellular Studies.- Joint Reports: Restriction Fragment Length Polymorphism (RFLP) with HLA Region Probes (Southern Blot).- Standardized Southern Blot Workshop Technique.- Organization and Design of the Southern Blot Component of the Tenth Histocompatibility Workshop.- Southern Blot Experiments: Data Processing.- RFLP Standardization Reports.- RFLP Standardization Report for DR Beta/SstI.- RFLP Standardization Report for DR Beta/PstI.- RFLP Standardization Report for DR Beta/KpnI.- RFLP Standardization Report for DR Beta/EcoRV.- RFLP Standardization Report for DR Beta/TaqI.- RFLP Standardization Report for DR Beta/BgIII.- RFLP Standardization Report for DR Beta/PvuII.- RFLP Standardization Report for DR Beta/EcoRI.- RFLP Standardization Report for DR Beta/HindIII.- RFLP Standardization Report for DR Beta/MspI.- RFLP Standardization Report for DR Beta/BamHI.- RFLP Standardization Report for: DR Beta/HincII.- RFLP Standardization Report for DQ Beta/SstI.- RFLP Standardization Report for DQ Beta/PstI.- RFLP Standardization Report for DQ Beta/KpnI.- RFLP Standardization Report for DQ Beta/EcoRV.- RFLP Standardization Report for DQ Beta/TaqI.- RFLP Standardization Report for DQ Beta/BglII.- RFLP Standardization Report for DQ Beta/PvuII.- RFLP Standardization Report for DQ Beta/EcoRI.- RFLP Standardization Report for DQ Beta/HindIII.- RFLP Standardization Report for DQ Beta/MspI.- RFLP Standardization Report for DQ Beta/BamHI.- RFLP Standardization Report for DQ Beta/HincII.- RFLP Standardization Report for DP Beta/SstI.- RFLP Standardization Report for DP Beta/PstI.- RFLP Standardization Report for DP Beta/KpnI.- RFLP Standardization Report for DP Beta/EcoRV.- RFLP Standardization Report for DP Beta/TaqI.- RFLP Standardization Report for DP Beta/BglII.- RFLP Standardization Report for DP Beta/PvuII.- RFLP Standardization Report for DP Beta/EcoRI.- RFLP Standardization Report for DP Beta/HindIII.- RFLP Standardization Report for DP Beta/MspI.- RFLP Standardization Report for DP Beta/BamHI.- RFLP Standardization Report for DP Beta/HincII.- RFLP Standardization Report for DO Beta/SstI.- RFLP Standardization Report for DO Beta/PstI.- RFLP Standardization Report for DO Beta/KpnI.- RFLP Standardization Report for DR Beta/EcoRV.- RFLP Standardization Report for DO Beta/TaqI.- RFLP Standardization Report for DO Beta/BglII.- RFLP Standardization Report for DO Beta/PvuII.- RFLP Standardization Report for DO Beta/EcoRI.- RFLP Standardization Report for DO Beta/HindIII.- RFLP Standardization Report for DO Beta/MspI.- RFLP Standardization Report for DO Beta/BamHI.- RFLP Standarization Report for Class I/SstI.- RFLP Standardization Report for Class I/PstI.- RFLP Standardization Report for Class I/KpnI.- RFLP Standardization Report for Class I/EcoRV.- RFLP Standardization Report for Class I/TaqI.- RFLP Standardization Report for Class I/BglII.- RFLP Standardization Report for Class I/PvuII.- RFLP Standardization Report for Class I/EcoRI.- RFLP Standardization Report for Class I/HindIII.- RFLP Standardization Report for Class I/MspI.- RFLP Standardization Report for Class I/BamHI.- RFLP Standardization Report for BF/SstI.- RFLP Standardization Report for BF/PstI.- RFLP Standardization Report for BF/KpnI.- RFLP Standardization Report for BF/TaqI.- RFLP Standardization Report for BF/BglII.- RFLP Standardization Report for BF/PvuII.- RFLP Standardization Report for BF/EcoRI.- RFLP Standardization Report for BF/HindIII.- RFLP Standardization Report for BF/MspI.- RFLP Standardization Report for BF/BamHI.- RFLP Standardization Report for BF/EcoRV.- RFLP Standardization Report for C2/SstI.- RFLP Standardization Report for C2/PstI.- RFLP Standardization Report for C2/KpnI.- RFLP Standardization Report for C2/EcoRV.- RFLP Standardization Report for C2/TaqI.- RFLP Standardization Report for C2/BglII.- RFLP Standardization Report for C2/PvuII.- RFLP Standardization Report for C2/EcoRI.- RFLP Standardization Report for C2/HindIII.- RFLP Standardization Report for C2/MspI.- RFLP Standardization Report for C2/BamHI.- RFLP Standardization Report for C4/SstI.- RFLP Standardization Report for C4/PstI.- RFLP Standardization Report for C4/KpnI.- RFLP Standardization Report for C4/EcoRV.- RFLP Standardization Report for C4/TaqI.- RFLP Standardization Report for C4/PvuII.- RFLP Standardization Report for C4/EcoRI.- RFLP Standardization Report for C4/HindIII.- RFLP Standardization Report for C4/MspI.- RFLP Standardization Report for C4/BamHI.- RFLP Standardization Report for 210H/SstI.- RFLP Standardization Report for 210H/PstI.- RFLP Standardization Report for 210H/KpnI.- RFLP Standardization Report for 210H/EcoRV.- RFLP Standardization Report for 210H/TaqI.- RFLP Standardization Report for 210H/BglII.- RFLP Standardization Report for 210H/PvuII.- RFLP Standardization Report for 210H/EcoRI.- RFLP Standardization Report for 210H/HindIII.- RFLP Standardization Report for 210H/MspI.- RFLP Standardization Report for 210H/BamHI.- RFLP Standardization Report for DR Alpha/SstI.- RFLP Standardization Report for DR Alpha/PstI.- RFLP Standardization Report for DR Alpha/KpnI.- RFLP Standardization Report for DR alpha/EcoRV.- RFLP Standardization Report for DR Alpha/TaqI.- RFLP Standardization Report for DR Alpha/BglII.- RFLP Standardization Report for DR Alpha/PvuII.- RFLP Standardization Report for DR Alpha/EcoRI.- RFLP Standardization Report for DR Alpha/HindIII.- RFLP Standardization Report for DR Alpha/MspI.- RFLP Standardization Report for DQ Alpha/SstI.- RFLP Standardization Report for DQ Alpha/PstI.- RFLP Standardization Report for DQ Alpha/KpnI.- RFLP Standardization Report for DQ Alpha/EcoRV.- RFLP Standardization Report for DQ Alpha/TaqI.- RFLP Standardization Report for DQ Alpha/BglII.- RFLP Standardization Report for DQ Alpha/PvuII.- RFLP Standardization Report for DQ Alpha/EcoRI.- RFLP Standardization Report for DQ Alpha/HindIII.- RFLP Standardization Report for DQ Alpha/MspI.- RFLP Standardization Report for DQ Alpha/BamHI.- RFLP Standardization Report for DP Alpha/SstI.- RFLP Standardization Report for DP Alpha/PstI.- RFLP Standardization Report for DP Alpha/KpnI.- RFLP Standardization Report for DP Alpha/EcoRV.- RFLP Standardization Report for DP Alpha/TaqI.- RFLP Standardization Report for DP Alpha/BglII.- RFLP Standardization Report for DP Alpha/PvuII.- RFLP Standardization Report for DP Alpha/EcoRI.- RFLP Standardization Report for DP Alpha/HindIII.- RFLP Standardization Report for DP Alpha/MspI.- RFLP Standardization Report for DP Alpha/BamHI.- RFLP Summary Reports.- DNA-RFLP Analysis: HLA-DR Beta Workshop Report.- RFLP Analysis of DQ-Beta Chain Gene: Workshop Report.- Workshop Report for the HLA-DP Region.- Final Workshop Report: HLA Class I RFLP.- Workshop Report of RFLP in C4, C2, BF, and 210H Genes.- Specificity Analysis of DRA Fragments in Core Cell Lines.- Specificity Analysis of DQA Fragments in Core Cell Lines.- Unusual DR-DQ Haplotypes.- Linkage Disequilibrium, Interlocus Association and Ancestral Haplotypes.- The Genomic Structure of Ancestral Haplotypes Revealed by Pulsed Field Gel Electrophoresis (PFGE).- Myasthenia Gravis: Joint Report.- Analysis of HLA Recombinant Families by Southern Blots.- Southern Blot Analysis of Rheumatoid Arthritis.- An RFLP Study of HLA-D Gene Polymorphism in Multiple Sclerosis.- DP RFLP Studies of the 72 Core Cell Lines Selected for the Southern Blot Protocol.- Analysis of Class II RFLP Patterns and T-Cell Clone Reactions.- HLA Class II Typing by the Workshop Defined RFLP Specificities in Unrelated Individuals.- RFLP: Sequence Interrelations at the DPA and DPB Loci.- Restriction Fragment Length Polymorphism of HLA Genes: Summary of the Tenth International Workshop Southern Blot Analysis.- Joint Report: cDNA.- First Domain Sequence Diversity of DR and DQ Subregion Alleles.- Summary Cross-Correlation of the Tenth International Histocompatibility Workshop Data.- A Display of Positive Correlations Obtained by Serology, Southern Blot Analysis, T-Lymphocyte Clones, and Two-Dimensional Gel Analysis Tested on the Reference Panel of B-Lymphoblastoid Cell Lines for Factors of the HLA System.- Workshop Participants.- Laboratory Addresses for Volume I.
