Immunology of HIV Infection

Leading experts provide the only comprehensive book examining all aspects of immune response and immune-based treatments for HIV infection. Contributions, divided into three sections, discuss basic mechanisms, immunopathogenesis of HIV infection, and immune-based therapies. Researchers thoroughly review vaccine-including prospects of T cell vaccine-and gene therapy for HIV infection. Additional topics include organization of HIV genes, the role of co-receptors in signaling of lymphocytes, and biological response modifiers. This reference is designed for basic and clinical researchers, internists, pediatricians, infectious disease specialists, neuropathologists, oncologists, and rheumatologists.

Section I. Basic Mechanisms. - 1 Genetic Organization of HIV. - 2 T-Cell Epitopes of HIV-1 Envelope Glycoprotein. - 3 B-Cell Sites in the HIV Glycoproteins. - 4 Lymphocyte Adhesion Coreceptors and Their Roles in HIV-1 Replication. - Section II. Immunopathogenesis. - 5 HIV in Lymph Node and Thymus. - 6 Effects of HIV-1 and HIV-1 Envelope Glycoproteins on Signaling Pathways in Human T Lymphocytes. - 7 Lymphocyte Apoptosis in HIV Infection. - 8 Biological Activities of HIV-Specific Peptides. - 9 Phenotype and Function of T Cells in HIV Disease. - 10 Cytotoxic T-Lymphocyte Responses to HIV: From Primary Infection to Aids. - 11 Type 1 and Type 2 Responses in HIV Infection and Exposure. - 12 Humoral Immunity to HIV-1: Lethal Force or Trojan Horse? . - 13 Autoimmunity in HIV. - 14 Cytokine Cascades in HIV Infection. - 15 Macrophage Functions in HIV-1 Infection. - 16 Dendritic Cell Functions in HIV Infection. - 17 Natural Killer Cells in HIV Infection. - 18 HIV and Complement. - 19 Polymorphonuclear Leukocyte Function in HIV. - 20 Mucosal Immunity in HIV Infection. - 21 The Putative Role of HIV-1 Envelope Proteins in the Neuroimmunology and Neuropathology of CNS Aids. - 22 Immunopathogenesis of Kaposi s Sarcoma. - 23 Pathogenesis of HIV-Associated Lymphoma. - Section III. Immune-Based Therapy. - 24 The Immunotherapy of HIV Infection with Drugs. - 25 Biologic Response Modifiers (Interleukins and Interferons). - 26 Thymic Hormones in the Treatment of Aids and Other Infectious Diseases. - 27 Growth Factors in the Treatment of HIV Disease. - 28 T-Cell Vaccination for HIV-Seropositive Patients. - 29 HIV Vaccines. - 30 Gene Therapy.