Japanese Encephalitis

This book provides a comprehensive overview of Japanese Encephalitis (JE), its pathobiology, and associated challenges for treatment and prevention. It focuses on various aspects of Japanese Encephalitis, including global epidemiology, genome organization and genotypes, virus-host interactions, immunopathogenesis, transmission dynamics, antibody-dependent enhancement, clinical characteristics, laboratory diagnosis, treatment, prevention, and control strategies. It provides a brief account of the Japanese encephalitis vaccine, their immunogenicity, protective ability, and impact of JE's vaccine in reducing the burden of the disease. It also helps in understanding the molecular and cellular factors involved in the JE virus neuro-invasion and inflammatory processes. The book uniquely presents cutting-edge information and provides an edited information source for clinicians, virologists, pathologists, and immunologists.

Chapter 1. Insights into the Japanese encephalitis virus-mediated acute encephalitis syndrome. - Chapter 2. Global trends in phylogenetic genotypes-based epidemiology of Japanese encephalitis virus. - Chapter 3. Transmission Dynamics of Japanese Encephalitis Virus. - Chapter 4. Structure, Genome organization and replication of Japanese encephalitis virus. - Chapter 5. Host immune response during Japanese encephalitis virus infection. - Chapter 6. Antibody Dependent Enhancement during Japanese encephalitis Virus Infection. - Chapter 7. Molecular and cellular mechanisms underlying neuropathogenesis of Japanese encephalitis. - Chapter 8. Clinical characteristics and differential clinical diagnosis of Japanese Encephalitis. - Chapter 9. Laboratory Diagnosis of Japanese Encephalitis. - Chapter 10. Treatment options and antiviral drug discovery for Japanese encephalitis. - Chapter 11. Vaccines for Japanese encephalitis. - Chapter 12. Co-infection with other flaviviruses during Japanese encephalitis. - Chapter 13. Survivors of Japanese encephalitis and associated neuropsychiatric complications. - Chapter 14. Transplacental transmission of Japanese Encephalitis Virus. - Chapter 15. Impact of Japanese encephalitis in adults: Risk factors and associated challenges.