Progress in sequencing and characterizing the human genome has transformed cancer genetics both conceptually and methodologically. In Prostate Cancer: Biology, Genetics, and the New Therapeutics, leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer, as well as its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer, and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth, progression, and stromal-epithelial interaction has revealed many new possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Among the cancer therapeutic modalities discussed are chemoprevention, radiotherapy, radical retropubic prostatectomy, the development of dendritic-cell based vaccines, differentiation therapies, and gene therapy.
Comprehensive and cutting-edge, Prostate Cancer: Biology, Genetics, and the New Therapeutics synthesizes all the major recent work that is not only rapidly unraveling the mysteries of prostate cancer, but also dramatically improving today's therapeutic approaches.
Inhaltsverzeichnis
I. Introduction.- 1 Building the Road to Defeat Prostate Cancer: A Dedication to Donald S. Coffey.- II. Cancer Genetics.- 2 Hereditary Prostate Cancer.- 3 AR Gene Alterations in Prostate Cancer Progression.- 4 Lethal Metastatic Human Prostate Cancer: Autopsy Studies and Characteristics of Metastases.- 5 Tumor Suppressor Genes in Prostate Cancer.- 6 Androgen Receptor Polymorphisms and Prostate Cancer Risk.- 7 The Genetic Epidemiology of Prostate Cancer: Closing in on a Complex Disease.- 8 Determination of Gene and Chromosome Dosage in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma by Molecular Cytogenetic Techniques.- 9 Genetic Alterations in Prostatic Intraepithelial Neoplasia (PIN).- 10 Xenograft Models and the Molecular Biology of Human Prostate Cancer.- 11 Comprehensive Analyses of Prostate Gene Expression.- III. Cancer Biology.- 12 The Role of Nuclear Matrix and Cytoskeleton in Cancer.- 13 The Role of Cell Adhesion Molecules in Prostate Development and Carcinogenesis.- 14 Ligand Dependent and Independent Activation of the Androgen Receptor.- 15 Tyrosine Kinases and Cellular Signaling in Prostate Cancer.- 16 Molecular Pathways Underlying Prostate Cancer Progression: The Role of Caveolin-1.- 17 Angiogenesis and Prostate Cancer.- 18 Prostate Specific Membrane Antigen.- 19 Targeting Antiapoptotic Genes Upregulated by Androgen Withdrawal Using Antisense Oligodeoxynucleotides to Enhance Androgen- and Chemo-Sensitivity in Prostate Cancer.- 20 Stromal-Epithelial Interaction: From Bench to Bedside.- IV. Cancer Therapeutics.- 21 Chemoprevention of Prostate Cancer.- 22 Anatomic Radical Retropubic Prostatectomy for Prostate Cancer.- 23 Radiation Therapy as Applied to Prostate Cancer: Clinical, Technical, and Biologic Considerations.- 24 Prostate Cancer Chemotherapy: Closing Out a Century and Opening a New One.- 25 The Role of Small Bioactive Peptides and Cell Surface Peptidases in Androgen Independent Prostate Cancer.- 26 Development of Dendritic Cell-Based Prostate Cancer Vaccine.- 27 Antiprogression Agents for Prostate Cancer.- 28 Human Gene Therapy for Urological Oncology.- 29 Chemoprevention Trials for Prostate Cancer.
