Bacterial Survival in the Hostile Environment

Variety of bacteria are present in our environment but only a few of these bacteria causes diseases in their hosts including humans. These bacteria face different stresses in the environment as well as inside the host and adapt number of strategies for their survival. In 5 parts Bacterial Survival in the Hostile Environment covers all tactics and strategies adopted by bacteria for their survival under stressed conditions and will be focused on mechanistic insights of pathogenic adaptations to host environments (acidic environment, microaerobic conditions, immune system stress, metal stress etc. , modulation of host pathways by pathogens for survival, dormancy, drug tolerance and resistance, proteins for stress survival). The content also includes different adaptation mechanisms of extremophiles to extreme environment, provides a complete and globally available advance knowledge related to bacterial survival from different perspectives and reviews the knowledge gaps and future prospects in the field of microbial adaptation for sustainable development of in the field of infection biology and pharmaceutics.

Part 1:
1. Pathogenic adaptation to host environment
2. Adaptation to acidic environment
3. Microaerobic conditions
4. Immune system stress
5. Metal stress

Part 2: Modulation of host pathways by pathogens for adaptation/survival
6. Modulation in glycolytic flux
7. Endoplasmic reticulum stress
8. Host Mitochondria
9. Apoptosis
10. Necrosis
11. Phagosome maturation
12. Autophagy regulation

Part 3: Dormancy, Drug Tolerance and Resistance
13. Growth regulation by microbes
14. Survival and reactivation strategies of pathogens in stress through heterogeneous population generation
15. Persisters
16. Antimicrobial resistance

Part 4: Proteins for stress survival
17. Chaperones
18. Ribosome associated proteins
19. Methyltransferases
20. Proteins responsible for growth regulation of bacteria during unfavourable conditions
21. Proteins involved in biofilm

Part 5: Adaptation to Extreme Environment
22. Adaptations to Ph
23. Temperature
24. Pressure
25. Halophilic adaptations
26. Radiation adaptation